T1 Mapping with CMR Is Highly Sensitive for Fabry Disease Independent of Hypertrophy and Gender Thompson et al: T1 mapping with CMR in Fabry Disease
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Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance
BACKGROUND Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in patients with Fabry disease even before left ventricular hypertrophy (LVH) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship of native T1 lowering prior to hypertrophy and other candidate early phenotype markers are unknown. Furthermore, the reproducib...
متن کاملECG, LVH and T1 changes in Fabry disease - implications for screening and understanding of the disease model
Background Fabry disease is a rare X-linked condition that results in storage of sphingolipids in multiple organs including the heart. The cardiac phenotype consists mainly of conduction abnormalities, left ventricular hypertrophy (LVH) and disease progression (fibrosis, arrhythmias and heart failure). CMR LGE classically shows basal inferolateral LGE. Native T1 mapping has recently shown a low...
متن کاملNative T1 mapping versus CMR Feature Tracking (FT) derived strain analysis for the assessment of cardiac disease manifestation in Anderson Fabry
Background Cardiovascular sequelae represent a leading cause of mortality in Fabry disease. Early detection of cardiac involvement is therefore a subject of considerable interest. Low native T1 values have been shown to be associated with echocardiographic markers of early systolic and diastolic dysfunction, even in those without left ventricular hypertrophy (LVH), and conceptually could be use...
متن کاملClinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2* and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
Parametric mapping techniques provide a non-invasive tool for quantifying tissue alterations in myocardial disease in those eligible for cardiovascular magnetic resonance (CMR). Parametric mapping with CMR now permits the routine spatial visualization and quantification of changes in myocardial composition based on changes in T1, T2, and T2*(star) relaxation times and extracellular volume (ECV)...
متن کاملT1 Mapping by CMR Imaging
Fro Ge He Sie infl La Ph Ma OBJECTIVES The purpose of this study was to prospectively investigate the diagnostic and prognostic impact of cardiac magnetic resonance (CMR) T1 mapping and validate it against left ventricular biopsies. BACKGROUND Extracellular volume (ECV) expansion is a key feature of heart failure. CMR T1 mapping has been developed as a noninvasive technique to estimate ECV; how...
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تاریخ انتشار 2013